More details on the profile of pregabalin use before the onset of withdrawal syndrome are given in Table 3, and a schematic representation of the manifestations of withdrawal syndrome is shown in Figure 6. Governments and researchers around the world are concerned about the recreational use of pregabalin, noting its growing prevalence and consumers’ often unsuccessful attempts to stop taking the drug. The object of the study is the phenomenon of recreational use of pregabalin in Ukraine. According to Healthcare Bluebook, a 60-day supply of 75mg Lyrica sells for a “fair price” of $472.
- If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Stopping the medicine suddenly may cause seizures or side effects including changes in behavior, dizziness, diarrhea, nausea, headaches, vomiting, irritability, thoughts of killing oneself, trouble with sleeping, nightmares, or tingling feelings.
- After discontinuation, withdrawal syndrome develops, including psychopathological, vegetative, neurological, and other physical symptoms.
- Pregabalin (PGB) is an alpha2-delta ligand of voltage gated calcium channels that displays analgesic, anxiolytic, and anticonvulsive properties 19.
5 Assessment of risk of bias in included studies
Additionally, pediatric populations were excluded, as the focus of this study was on adult patients. Duplicate studies were excluded to avoid data duplication and ensure the integrity of the analysis. In the case of buy pregabalin 75 mg online duplicate studies reporting related information in different publications, the decision was made to group them into a single study to avoid duplication of basic characteristics and to ensure that each variable was accounted for only once. However, relevant information was extracted from each duplicate study for inclusion in the analysis. This allowed the utilization of complementary data and ensured a comprehensive evaluation of the available results without incurring unnecessary redundancy. Studies with incomplete data or those in which variables were not comparable were also discarded, as this could have affected the validity and reliability of the results.